After his first 3 months of Cannabis Oil use, My Father’s Tumors decreased up to 80%! his oncologist was shocked.I am so happy with how the Cannabis oil have changed the life of my father.Not only do I truly believe it has been the reason his tumors are decreasing, but also he is off his anxiety and sleeping meds! Something that he had relied on so much before, now replaced with a natural cure (Cannabis Oil). We Bought high quality Cannabis Oil from E-MAIL:(email@example.com) or (SKYPE: medical fourtwenty) and Our Delivery was 100% Safe. This connection we made has truly done so much for our family already.” You can also get Canasol for those suffering with Glaucoma. “Canasol is the only Medication that Treats Glaucoma Effectively”
Studies present evidence of diminished gray matter in the hippocampus region of cannabis users. Conclusion: protective effects of cannabidiol (CBD)
Study Author(s): Demirakca, Traute;Sartorius, Alexander;Ende, Gabriele;Meyer, Nadja;Welzel, Helga;Skopp, Gisela;Mann, Karl;Hermann, Derik;
Institution: Department of Neuroimaging, Central Institute of Mental Health, J 5, 68159 Mannheim, Germany.
New research has indicated that cannabinoids may hold the key to successfully treating neurogenerative diseases such as Alzheimers Disease. Undertaken by neurologists Veronica Campbell and Steven Fagan of the University of Dublin they were able to explain how the compounds (cannabinoids), which target the endocannabinoid system, are the basis for treating a range of neurodegenerative diseases successfully. The treatment is believed to have very minimal side effects.
Neurodegenerative disease is described as a loss of structure or function of the neurons; that worsens progressively resulting in the death of neurons. Many neurodegenerative diseases, including Parkinson’s, Alzheimer’s, and Huntington’s, occur due to this neurodegenerative process.
Asked to explain how neurodegeneration is linked to the ageing process, Fagan described the connection between people’s age contrasting against their brains, which also experience ageing effects. When a brain is aged, it becomes highly susceptible to many diseases. Fagan explains that as there becomes a larger ageing population with each new year, the incidence of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease is likewise rising with the increased population of seniors.
Aging naturally leads to changes in the neural chemistry, most notably in the destruction of brain cells. The brain becomes increasingly susceptible to degenerative disorders, such as Parkinson’s and Alzheimer’s diseases. “Current therapies focus on treatment of the symptoms and attempt to delay the progression of these diseases, but there is currently no cure,” Fagan explains. That is until the possibilities of this new treatment come to full realisation.
Fagan’s and Campbell’s research, which builds upon earlier studies by Campbell on Alzheimer’s disease, has been published in the British Journal of Pharmacology. The study suggests that such brain- and age-related conditions can benefit from “the modulation of the endogenous cannabinoid system.”
The researchers reached this conclusion by examining several brains obtained from deceased Alzheimer’s patients. These examinations, coupled with studies on animals, showed that alterations in components of the cannabinoid system occur. Such a study strongly suggests that the cannabinoid system either contributes to, or is altered by, the pathophysiology of Alzheimer’s disease.
From this an important therapeutic target is presented, because alterations in the endocannabinoid system have been detected in patients who are suffering from not only Alzheimer’s disease, but also Parkinson’s and Huntington’s diseases.
Thus, for further study, the neurologists looked at “pharmacological manipulation of the endogenous cannabinoid system, as well as application of phytocannabinoids and synthetic cannabinoids.”
The way that the endocannabinoid can be “manipulated” or modulated to act against the neurodegenerative diseases is through activation by the cannabinoid THC. THC, or tetrahydrocannabinol, is the major psychoactive component of marijuana in the cannabis plant.
Cannabinoids affect cannabinoid receptors, such as receptor CB1, which are found in the brain and the central nervous system. The activation can help to regulate aspects of the brain’s inflammatory response, including halting the release of pro-inflammatory chemicals. These receptors are targets for the phytocannabinoids isolated from the cannabis plant (THC) as well as synthetic preparations.
Specifically, Fagan said that the research group has been looking at dronabinol, a chemical derived from THC (synthesized THC is generally referred to as dronabinol) that stimulates the CB1 receptor.
The research team used dronabinol in a pilot study with Alzheimer’s patients in whom it improved nocturnal motor activity and reduced agitation and aggression, without undesired side effects. From the study, the key aspect appeared to be “the anti-inflammatory and antioxidant properties” of the chemical. This is in keeping with the one factor that links the different neurodegenerative diseases together: neuroinflammation. Fagan surmises that the research “highlights the beneficial effects of cannabinoid treatment.”
The conclusion is in keeping with earlier studies, such as one undertaken at the University College London, that have shown that inflammation and the endocannabinoid system have been linked to another neurodegenerative disease: multiple sclerosis. In addition, some earlier trials have shown that THC could prevent the loss of dopamine neurons in animal models of Parkinson’s disease.
The Irish research is considered important because, hitherto, there were no known treatments that can slow down the progression of brain-associated disorders. British and Irish research is prohibitive in relation to the use of marijuana in human trials. Nonetheless, Fagan is “not averse to trials which look at the use of marijuana and its active ingredients, like THC, in human trials.”
With the beneficial effects of THC highlighted, how do the elderly feel about taking medical marijuana or derivatives? Discussing the issue with some residents at a day center for pensioners in a suburb of north London in the U.K., the reactions were generally positive.
One woman, Patricia Howe, said: “If I can take something to keep my faculties in check, then it sounds like a good thing.” Asked about the difference between a synthetic pill and smoking medical marijuana, she added: “I’ve smoked pot in the past; it did me no harm. If it helped, I’d be willing to try it again.”
A similar reaction was given by Kirsty Froome when asked about a pill: “It sounds like something we should take.” However, in response to the question of inhaling medical marijuana, she said: “I don’t smoke, but I’d be happy to pop a pill – I take enough of them for my other ailments.”
With the idea appearing favorable to people in their sixties and seventies, and with a growing body of research providing increased understanding of the physiological role of endocannabinoids, a therapeutic opportunity appears to be expanding the use of medical cannabis to address several different types of neurological diseases.
Cannabis and the studies backing the cure
Much of the debate associated with the legality of medicinal cannabis is due to a perceived lack of clinical data supporting its value. There are numerous studies showing the positive effects of cannabis on all kinds of cancer. Obviously through legalisation, we are free to engage in further studies and help save those suffering from one of healthcare’s biggest mysteries – the cure for cancer
Findings: THC and other cannabinoids inhibit the growth of tumours. Cannabinoid delivery was deemed safe and was achieved with zero psychoactive effects. THC decreased tumour cells in two out of the nine patients.2.The Journal of Neuroscience published a study examining the biochemical events in both acute neuronal damage and in neurodegenerative diseases that worsen progressively with time. They conducted a magnetic resonance imaging study that investigated THC to find that it minimised neuronal injury in rats. Conclusive evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.
3. A study published in The Journal of Pharmacology And Experimental Therapeutics already acknowledged the fact that cannabinoids have been shown to possess antitumor properties. This study examined the effect of cannabidiol (CBD, non psychoactive cannabinoid compound) on human glioma cell lines. The addition of cannabidiol led to a dramatic drop in the viability of glioma cells. Glioma is the word used to describe brain tumour. The study concluded that cannabidiol was able to produce a significant antitumor activity.
4. A study published in the Journal Molecular Cancer Therapeutics outlines how brain tumours are highly resistant to current anticancer treatments, which makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of patients suffering from this disease. This study also demonstrated the reversal of tumour activity in Glioblastoma multiforme.
7. A study published in the Journal Molecular Cancer showed that THC reduced tumour growth and tumour numbers. They determined that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis and impair tumour angiogenesis (all good things). This study provides strong evidence for the use of cannabinoid based therapies for the management of breast cancer.
8. A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) determined that cannabinoids inhibit human breast cancer cell proliferation.
11. A study published by the US National Library of Medicine, conducted by Harvard Medical School investigated the role of cannabinoid receptors in lung cancer cells. They determined its effectiveness and suggested that it should be used for treatment against lung cancer cells.
14. Another study published by the US National Library of Medicine determined that clinical testing of CBD against prostate carcinoma is a must. That cannabinoid receptor activation induces prostate carcinoma cell apoptosis. They determined that cannabidiol significantly inhibited cell viability.
17. A study published in the US National Library of Medicine conducted by the Department of Pharmacology and Toxicology by Virginia Commonwealth University determined that cannabinoids induce apoptosis in leukemia cells.
Can medical cannabis improve autism?
American mother Marie Myung-Ok Lee says medical cannabis is completely safe for her autistic son – and the dramatic improvement in his condition says more than enough.
Cannabis and its effect on Sleep
Does Cannabis help you sleep more soundly?
Just like one may pour a glass of wine at the end of a rough day, many people find cannabis to be a relaxing alternative for winding down. With more research presenting itself regarding the therapeutic uses of cannabis, it appears medical cannabis can improve sleep.
5 Ways Cannabis Improves Sleep
1. Easier Falling Asleep
Early research on medical cannabis and sleep show that the constituent known for its psychotropic effects (THC), can significantly reduce the time it takes for those who struggle to sleep, to fall asleep.
In a small study published in 1973, THC decreased the time it took for nine subjects who suffered from insomnia to fall asleep. The difference was over an hour on average. Researchers also noted that in having too high a dose, the sleepiness effect could diminish.
THC was also found to ease the anxiety of falling asleep in a 2013 study involving healthy subjects.
2. Longer Sleep
Early studies also revealed that taking either THC or CBD before bed had the potential to increase total sleep. Increasing the dose of THC did tend to increase the amount of time the subject would spend sleeping.
3. More Deep Sleep
Some of the more interesting effects of cannabis with sleep have to do with its ability to improve the quality of sleep within sleep cycles. Studies show that THC can increase he amount of slow-wave sleep, also known as deep sleep, that users experience during their slumber.
Deep sleep is believed to play a significant role in the restoration process that occurs during sleep.
What’s more, experts believe that the most damaging effects of sleep deprivation result from a lack of slow-wave sleep. For example, research has shown that reduced slow-wave sleep can be a reliable predictor of high blood pressure in older men.
4. Shorter REM Sleep
Another way medical cannabis affects the sleep cycle is a reduction in REM sleep. Many people who smoke before bed report a lack of dreaming, which only occurs during REM sleep.
While less REM sleep could be seen as a negative effect of marijuana use, scientists are still not sure what purpose REM sleep serves.
However, people who quit after using cannabis on a frequent basis often experience an increase in REM sleep, also known as the “REM rebound” effect, which is accompanied by an increase in dreaming and restlessness during sleep. But this effect tends to wear off within days or weeks, depending on the individual.
5. Better Breathing
When it comes to medical use, marijuana could offer an incredible benefit to the approximately 25% of men and 9% of women who suffer from a disorder called sleep apnea.
Sleep apnea is characterised by disrupted breathing during sleep and has been linked to some severe conditions, including diabetes and heart problems. Unfortunately, the vast majority of sleep apnea sufferers remain undiagnosed and untreated.
Even of those who seek treatment, many eventually give up on wearing a CPAP mask every night.
But that’s where marijuana may help, as researchers are currently trialling THC as an alternative, with early results already showing promise.
To understand Post Traumatic Stress Disorder is to understand anxiety on a whole different level. PTSD causes a severe disruption to one ‘s life oftentimes making it impossible to engage in normal activities. PTSD arises out of having exposure to consistent levels of mental and emotional stress. It also arises out of experiencing a significant trauma event – something which would cause distress to anyone (not just those who are anxious already.) PTSD affects the sleep wake cycle. Vivid recall of traumatic events oftentimes occurs at night. Mental and physical disturbances disrupt the onset of sleep or riddles patient’s sleep with terror dreams. Patients can get stuck in a feeling of shock, dependent on the severity and repetition of the trauma recall.
Serotonin reuptake inhibitors:
- fluoxetine (Prozac)
- sertraline (Zoloft)
- paroxetine (Paxil), etc.
Typical Side Effects from Antidepressants
- weight gain
- dry mouth
- sexual difficulties
Anti-anxiety medication is oftentimes prescribed for PTSD symptoms. This is only for a short term treatment due to the addictive nature of most anxiety medications (benzodiazapam).
Receiving consistent and supportive trauma focused psychological therapy is considered the first and best PTSD treatment. Patients who have been exposed to severe psychological trauma will each deal with the situation individually. Directly after a patient has experienced a traumatic event, many will ask their GP for guidance. It is up to a patient’s GP to be fully aware of a patient and their mental state. Emotional support is not usually available through one’s GP and therefore should be offered to a PTSD patient affordably with immediacy, regardless of how they appear.
Medicinal Cannabis Treatment for Post Traumatic Stress Disorder (PTSD)
Research published in the journal of Neuropsychopharmacology., showed that by administering synthetic cannabinoids to rats after they experienced a traumatic event, they prevented them from exhibiting the behavioral and physiological symptoms of PTSD. The synthetic cannabinoids did this by triggering changes in the brain centers associated with formation and storage of traumatic memories.
In another study, researchers at the University of Haifa in Israel were able to halt the development of PTSD in rats studied by treating them with cannabinoids. Led by Dr. Irit Akirav from the Dept of Psychology., the research team used rat subjects because of the similarity they have to humans in trauma response. As is known with PTSD, people who suffer from the symptoms are easily set off by triggers or reminders of the trauma. Triggers are very personal to the individual and will not be the same for everyone. The team of researchers found that in dosing the rats with cannabinoids following a traumatic event, this could in fact make them immune to future triggers. The treated rats showed no evidence of PTSD. Rats that were not treated however, experienced PTSD alongside a host of deficiencies impairments in memory extinction, changes in the sensation of pain and increased panic behaviour.
Post Traumatic Stress Disorder (PTSD) Statistics in Australia
1.4 million Australians at any one time* have Post Traumatic Stress Disorder (PTSD).
(*Australian Bureau of Statistics – 6.4% of 21,530,081 Australians)The Australian Centre for Post Traumatic Mental Health estimates that up to 10 per cent of people will suffer from PTSD at some point in their lives.
Other symptoms experienced in PTSD.
Misunderstood feelings of shame, despair, or hopelessness.
Inability to control emotions
Mounting problems with friends and family
Self destructive behaviour
Changed belief system
Causes of PTSD
- Post-traumatic stress disorder (PTSD) oftentimes develops soon after experiencing a traumatic event that threatens ones safety or makes one feel helpless.
- PTSD is not just afflicting the battle-scarred soldiers., though military combat is the most common cause of PTSD in men
- Post-traumatic stress disorder (PTSD) can affect anyone who was involved or personally experienced the “traumatic event”.
- PTSD develops on an individual basis from person to person.
- PTSD can take weeks, months, years to appear., though it is more often known to develop soon after an overwhelming life situation, “trauma”.
What would be considered a traumatic event?
A traumatic event ordinarily implies one which a person witnesses or experiences something which threatens the safety of, or threatens ones livelihood. It could be a serious injury or even sexual violence.
Traumatic events that can lead to PTSD include:
- Natural disasters
- Car or plane crashes
- Terrorist attacks
- Sudden death of a loved one
- Sexual or physical abuse
- Partner Infidelity
- Childhood neglect
Symptoms of PTSD – Post Traumatic Stress Disorder
FLASHBACK / RELIVING THE TRAUMATIC EVENT – Patient is triggered by something sensory., which then causes them to relive the traumatic event. Mentally, emotionally and physically the patient can re-experience the event. The intense fear signaling fight or flight response, increased cortisol levels, heart rate, hormonal shifts.AVOIDANCE OF REMINDERS OR TRIGGERS – Patients experiencing the mental and emotional distress of PTSD will subconsciously aim to avoid any and all situations that trigger memories of the trauma ie) War veterans may avoid watching movies or television programs that have weaponry. Some patients have a constant need to stay busy and will set themselves up so that they consistently avoid dealing with their past exposure to trauma.
FEELING NUMB – In an effort to avoid painful memories, patients will protect themselves by being and becoming completely uninvolved. Patients may lose interest in the activities they once used to love. Patients may avoid developing relationships and friendships due to their discomfort with feeling emotionally connected. Patients oftentimes completely forget the trauma.
NERVOUS WRECK – This person’s response to continued stress has created an oversensitivity to any and all signals of stress. This person will consistently feel like they are in high alert. Ready for any danger big or small., and with no effective gauge to measure the difference between both. “Fried” “Keyed Up” Nervous wreck symptoms include having an increased emotional arousal, intense mood variations, quick to anger or upset, patient is sitting in a state of constant fear / anxiety, sleep disturbances are prevalent, and difficulty concentrating.
MENTAL HEALTH PROBLEMS AND ADDICTION – Other health issues present themselves once someone develops PTSD. It is common to experience depression or anxiety, alongside PTSD. Some people find using alcohol or drugs helps them cope with the traumatic memories. This can worsen PTSD., as dealing with the difficult emotions is necessary for healing from the traumatic experience.
Clinical Studies / References:
- Radiation Therapy
- Biologic or Targeted Therapy
- chemotherapy drugs – side effects from chemotherapy drugs
- hormone therapies
- biological therapies
Medicinal Cannabis Treatment for Cancer : Chemotherapy Treatment
Chemotherapy is a treatment for cancer which has a number of side effects that can make it nearly impossible for a patient to maintain good health. One of the main side effects from chemotherapy is nausea and vomiting. Nausea and vomiting makes it hard to eat, therefore necessary nutrients are often omitted from the diet causing a worsened condition. For some, it can even equate to anorexia and body wastage. Medical cannabis treatment for cancer gives the patient the ability to feel hunger and eat to heal. Nausea subsides along with the vomiting often caused by chemotherapy. CBD (Cannabidiol), one of the five cannabinoids found in medical cannabis has also been found to inhibit tumor growth in leukemia and breast cancer.More about chemotherapy drug side effects and medical cannabis for nausea and vomiting
Medicinal Cannabis Treatment for Cancer
MCCA does not recommend our products be used in isolation as a treatment, cure or prevention for cancer or any other neoplastic diseases, rather cannabinoid product may be used as an adjunct to conventional therapies.
Statistics: Population Diagnosed with Cancer in Australia
An estimated 128,000 new cases of cancer are expected as being diagnosed in Australia, with that number set to rise to 150,000 by 2020
1 in 2 Australian men and 1 in 3 Australian women will be diagnosed with cancer by the age of 85
Cancer is a leading cause of death in Australia – more than 43,200 people died from cancer in 2011
Cancer accounted for about 3 in 10 deaths in Australia
Around 19,000 more people die each year from cancer than 30 years ago, this is due mainly to population growth and ageing. However, the death rate (number of deaths per 100,000 people) has fallen by more than 16%
66% of people diagnosed with cancer in Australia are still alive five years after diagnosis
The survival rate for many common cancers has increased by 30 per cent in the past two decades
The most common cancers in Australia (excluding non-melanoma skin cancer) are prostate, colorectal (bowel), breast, melanoma and lung cancer. These five cancers account for over 60% of all cancers diagnosed in Australia
Over 434,000 people are treated for one or more non-melanoma skin cancers each year, with 543 people dying in 2011
What is Cancer?
Cancer causes unregulated and rapid cell growth
The cancerous cells invade and destroy surrounding healthy tissue
Cancer normally starts out in one part of the body, but can be spread through the bloodstream and lymphatic system
There are more than 200 types of cancer that effect humans
Causes of Cancer
one in nine cancers, and one in five cancer deaths, are due to smoking
about 3% of cancers are related to alcohol consumption
many cancers occur as a direct result of dietary influences
from infectious agents or exposure to radiation (especially skin cancers from ultraviolet radiation)
some cancers result from inherited ‘faulty’ genes
Symptoms of Cancer
> Jaundice > Fever> Extreme Tiredness > Unexplained Weight Loss
> Weakness > Dizziness
> Coughing > An enlarged or misshapen mole
> Lump > Pain
> Migraine > Hyper-pigmentaion
> Reddish skin > Itching
> Excessive hair growth > Long term constipation
> Sores that don’t heal > White patches inside the mouth or spots on the tongue
> Unusual bleeding > Nagging cough or hoarseness
Anti-tumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines (2003)
Research was conducted to further explore the hypothesis that CBD had anti-tumour qualities, within a lab setting. It was found that CBD significantly dropped the viability of tumour cells, suggesting that CBD has practical anti-tumour applications. Published in The Journal of Pharmacology and Experimental Therapeutics.
Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity (2001)
This research set out to examine the effects of THC on acute brain damage and degenerative brain disease. It was concluded that THC acts to protect the brain from degenerative diseases. Published in The Journal of Neuroscience.
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme (2006)
This study was the first that set out to explore the anti-tumour qualities of cannabinoids within a clinical setting. They had positive results, finding that THC and other cannabinoids acted to inhibit tumour growth within patients. Published in the British Journal of Cancer.
Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (2006)
This research acknowledges the anti-tumour effects of THC, but claims it is problematic because of its psychoactive properties. To this end, they set out to assess the effects of the other cannabinoids. It was found that CBD showed promising anti-cancer qualities that should be investigated further. Published in The Journal of Pharmacology and Experimental Therapeutics.
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (2010)
This study set out to determine the effects of CBD on breast cancer cells. It was found that it inhibited the growth and spread of these cancer cells. It was also found that CBD significantly reduced tumour mass. Published in the US Library of Medicine.
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition (2010)
This research outlines experiments that were conducted to assess the effects of cannabinoids on the highly aggressive ErB2-positive breast cancer. They concluded that cannabinoids appeared to reduce both tumour growth and the amount of tumours present, strongly suggesting that it has a real application for the therapeutic treatment of breast cancer. Published in the journal Molecular Cancer.
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo (2008)
Research was conducted to explore the effects of THC on epithelial growth factor-induced lung cancer – a particularly aggressive, and chemotherapy resistant form of cancer. It was found that THC played a significant role to inhibit the cancers growth, warranting further research into the matter. Published in the journal Oncogene.
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 (2011)
This Research sought to investigate the effects of CBD on the invasiveness of lung cancer. It was found that cannabinoids inhibited the invasiveness of primary tumour cells within lung cancer patients. Published in the US National Library of Medicine.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis (2011)
Research was conducted in order to ascertain the role of cannabinoid receptor activation in lung cancer. It was found both inhibit the growth of cancerous cells, as well as increase their apoptosis – the natural process of cell death. Published in the US National Library of Medicine.
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production (2003)
This study outlines how the activation of cannabinoid receptors within the prostate causes anti-prolific effect in cancer cells, having large implications into the treatment of prostate cancer. Published in the US National Library of Medicine.
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications (2012)
This study conducted a meta-review of many other previous prostate cancer research papers to determine whether cannabinoids had a practical clinical application. It concluded that it would be in everyone’s best interest to conduct clinical trials involving medical cannabis. Published in the US National Library of Medicine.
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms (2013)
This Research set out to expand on the previously researched notion that cannabinoid receptor activation caused cell death within prostate cancer cells. The research found significant positive results and concluded that the data supported the clinical testing of CBD in prostate cancer patients. Published in the US Library of Medicine.
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma (2006)
This study set out to explore whether cannabinoids inhibited cancer cells in lymphoma. It outlines how cannabinoids were found cause growth inhibition and cell death within mantle cell lymphoma (blood cancer). Published in the journal Molecular Pharmacology.
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukaemia T cells is regulated by translocation of Bad to mitochondria (2006)
This Research outlines how it assessed the use of cannabinoids to cause apoptosis (the regulated and natural death of cells). It gained positive results, finding that cannabinoids do indeed cause the death of cancerous leukaemia cells. Published in the US National Library of Medicine.
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation (2008)
This research aimed to determine what the effects cannabinoid receptor activation on lymphoma were. It was found that cannabinoid receptor activation reduced the multiplication and growth of lymphoma, as well as causing some cancer cells to die. Published in the International Journal of Cancer.
Cannabinoids inhibit cellular respiration of human oral cancer cells (2010)
This research aimed to study the effects of cannabinoids on how cancerous cells respire within types of oral cancer. They found that cannabinoids inhibit the cancer cells respiration and are thus toxic to them. This implies that cannabinoids could be used for the treatment of oral cancer. Published in the US National Library of Medicine.
Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy (2011)
This research aimed to determine how THC effects cancerous cells within the liver. It was found that THC reduces the growth and effectiveness of these cancerous cell, implying that THC as a therapeutic treatment should be explored further. Published in the US National Library of Medicine
Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes (2006)
This study suggests that pancreatic tumour tissue appears to have a much higher number of cannabinoid receptors when compared to that of normal pancreatic tissue. The study found that when cannabinoids were administered, cancer cells started dying through apoptosis, leading to a reduction in tumour growth and is spread. Published in The American Journal of Cancer.
Clinical Studies / References:
Medical Cannabis Clinic of Australia (MCCA) does not claim that any of its products are infallible or unfailing, nor does MCCA claim that all products will work in all cases of any specific condition. Inappropriate use can be harmful, use only as directed.
Published by Yahoo News telling the story of an Autistic boy, Kalel Santiago, 9, who spoke his first words shortly after he began cannabis-derived CBD-oil treatments.
Summary: Kalel Santiago of Puerto Rico, only nine years old, has endured struggles due to Autism. Diagnosed with a rare childhood cancer called neuroblastoma at just ten months of age, he has spent over two years undergoing a variety of treatments including surgery, chemotherapy and radiation. Then came the subsequent diagnosis: a severe and non-verbal autism.
Educating themselves thoroughly on autism, the parents looked for other autism treatment options. Trying out different schools and therapies, they eventually found a special surf-therapy school located by their home. An April fundraising event for that program opened their eyes to a treatment soon to change their lives: Hemp oil, rich in the compound cannabidiol (CBD). As it were shown, at least anecdotally, this cannabis treatment would offer the Santiago’s effective therapy, easing the symptoms of both epilepsy and autism.
Taking home a tiny sample bottle of spray, the parents began giving their son twice daily doses, as indicated on the label, right into his mouth. The results, they say, were startling: Kalel began to talk — in only two days.
© Yahoo News
What is the difference between all of the cannabis extractions on the market?
CBD oil – Cannabis Oil – Hemp oil – CBD hemp oil
There is much confusion when it comes to identifying the difference between the medicinal cannabis and its extracted cannabinoid treatment. CBD oil, Cannabis Oil and Hemp Oil could almost be referencing the same standard cannabis oil., due to the lack of differentiation available to the public. The internet uses all of these terms interchangeably and yet, they are not the same, nor is the quality of the final product.
1) Cannabis Oil can contain many different constituents and typically will have multiple cannabinoids present, alongside terpenes, flavonoids and contaminants if not extracted pharmaceutically and tested thoroughly.
2) CBD oil is an extraction of the powerful CBD cannabinoid, responsible for the multiple treatment variations it embodies. It can be extracted from industrial hemp stalks and leaves, thus some CBD oil available online is actually CBD Hemp Oil. CBD Oil is also extracted from the Cannabis Plant and flower.
CBD HEMP OIL
3) CBD Hemp Oil is the extraction of CBD from the hemp plant, but it is extracted from the stalks and leaves of the industrial hemp plant. Hemp is cheap and legal in most parts of the world. CBD Hemp potency is much less than that of the CBD extracted from the Cannabis plant/flower.
PURE CBD OIL
4) Pure CBD Oil is the extraction from a CBD Rich Cannabis Plant. The CBD Rich cannabis plant is usually genetically reproduced to yield higher levels of CBD. Oil is then purified, removing all contaminants to result in a CBD rich, low THC medicine which is 100% legal for medical treatment in Australia.
5) Hemp Oil is sometimes confused with CBD oil because both are low in THC and contain CBD. Though hemp oil does contain low levels of CBD, typically less than 25 parts per million (ppm), CBD extracts produced from cannabis flowers are up to 15 percent CBD (150,000 ppm) CBD is not a product or component of hemp seeds. Hemp oil contains far less CBD (cannabidiol) than CBD-rich cannabis oil and a large amount of industrial hemp is required to extract a small amount of CBD. The risk of contaminants is increased with hemp as a “bio-accumulator”—meaning the plant naturally drawns toxins from the soil.
Since the mid-1970s, medical scientists have already known for cannabinoid compounds and their abilities on a treatment of cancer and cancerous cells. Certainly, there are far more studies since the 70’s and today, we can finally identify the mechanism of action for cannabinoid therapy in its cure. As cannabis falls within a grey area of legality, it hasn’t been endorsed like other medicines by pharmaceutical companies. The limited channel provided in promoting its benefits means that many of the public are skeptical and unaware of its advantages. Chemotherapy has been the only recommended treatment when someone is diagnosed with cancer, yet on a global scale, we are anticipating a global shift in the years to come.
Laboratory tests conducted in 2008 by a group of scientists formed as a joint research effort between the countries Spain, France and Italy, and published in The Journal Of Clinical Investigation, revealed how the active ingredient in cannabis, (tetrahydrocannabinol or THC, functions providing “a potential” cure for brain cancer by inducing human glioma cell death. This cell death is done through stimulation of autophagy.
For those of you, unfamiliar with the terminology, autophagy is Autophagy is a physiological process in the body responsible for the destruction of cells in the body. Autophagy helps the body to maintain homeostasis by protein degradation and by the turnover of the destroyed cell organelles so that new cells can form. This study also revealed that via the same biochemical process THC could halt a multitude of cancer types, affecting multiple cells in the body.
There are other studies published that show how cannabinoids work by various mechanisms. Some inhibit cell growth, induce cell death, and inhibit tumor metastasis.
While cannabinoids effectively target and kill cancerous cells, they do not affect healthy, normal cells. They also may potentially protect healthy cells against cellular death. Moreover, cannabinoids are also researched for an ability to modulate pain and inflammation as they bind to special receptors in the brain, much like opioid derivatives that are commonly prescribed today.
Further evidence to support the effects of cannabis extract on malignant cancer cells comes from the real life experience of individuals who have successfully overcome cancer by using cannabis oil. Examples include a patient, who managed to cure completely his skin cancer by directly applying cannabis oil onto the affected areas of the skin, as well as another, who recovered from a severe head injury with the aid of hemp oil.
One of the cannabinoids that have very impressive medical properties is cannabidiol or CBD. Cannabidiol unlike THC is a non-psychoactive compound. It is regarded by some as the medical discovery of the 21st century. Research indicates that CBD can relieve convulsions, reduce inflammation, lower anxiety and suppress nausea while also inhibiting cancer development. Also, CBD has exhibited neuroprotective properties, reducing symptoms of dystonia and proving just as effective as regular antipsychotics in the treatment of schizophrenia.
What stands out is that from the vast amount of research and data available, as well as the personal experiences of cancer survivors, is that no chemotherapy currently being used medically can match the non-toxic anti-carcinogenic and anti-tumorigenic effects of these natural plant compounds.
This blog is a summary of information from the following references and is meant for educational purposes only. It contains a mixture of anecdotal and pre-clinical data and is in no way intended to be used to diagnose, prescribe or treat any condition of the body. This information should not be used as a substitute for proper medical counselling with a medical professional.